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Which statement is incorrect concerning immune checkpoint inhibitors?
Which statement is incorrect concerning immune checkpoint inhibitors?a) They enhance the immune system's ability to recognize and attack cancer cells.
b) They target specific proteins on immune cells to regulate their activity.
c) They may lead to autoimmune reactions due to overstimulation of the immune system.
d) They primarily inhibit the production of cancer cells.
Final answer:The incorrect statement about immune checkpoint inhibitors is that they primarily inhibit the production of cancer cells. So the correct answer is d) They primarily inhibit the production of cancer cells.Explanation:The statement that is incorrect concerning immune checkpoint inhibitors is 'd) They primarily inhibit the production of cancer cells.' Immune checkpoint inhibitors work by enhancing an immune response against cancer cells, rather than directly inhibiting the production of the cells themselves. These inhibitors target specific proteins on immune cells, such as PD-1 and PD-L1, to regulate and boost the immune system's ability to recognize and attack cancer cells.This can sometimes lead to overstimulation of the immune system and may result in autoimmune reactions, which shows that the immune system is actively engaged due to the therapy. Understanding the balance between therapeutic efficacy and potential adverse events is critical for the effective use of these treatments. One of the most well-known examples of immune checkpoints involves the proteins PD-1 and PD-L1. PD-1 is found on the surface of T-cells, which are crucial components of the immune response. Cancer cells can express PD-L1, which interacts with PD-1, effectively protecting them from immune attack. By using checkpoint inhibitors that block this interaction, the therapy removes the 'cloak' that cancer cells use to hide from the immune system, allowing T-cells to identify and destroy them....