Final answer:Osteoclasts are primarily found on the surface of bone tissue where they break down bone matrix during the process of bone remodeling or repair. They balance their activity with osteoblasts, which form new bone, maintaining overall bone health. Submembranous sites include compact bone's osteons and spongy bone's trabeculae where osteoclast activity is prominent.Explanation:The major submembranous sites of osteoclasts are related to their function in bone resorption. Osteoclasts are large multinucleated cells that play a key role in the breakdown and remodeling of bone by dissolving bone matrix through the action of lysosomal enzymes and acidification via hydrogen ions produced by carbonic anhydrase II. These cells are typically found on the surface of the bone tissue, especially where the bone is being remodeled or repaired. The balance of activity between osteoclasts and osteoblasts, which are responsible for bone formation, is crucial for maintaining healthy bone structure.Osteoblasts deposit bone material into the matrix, and, as they become surrounded by the matrix, they mature into osteocytes. These osteocytes are found in lacunae of the bone and help maintain the bone matrix. Additionally, compact bone contains structures called osteons, while spongy bone is comprised of trabeculae. Osteoclasts help regulate calcium and phosphorus levels in the blood by resorbing bone and releasing these important minerals....

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